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Lupus Death RateLangchuang Recipes on Lupus Erythematosus

Effect of regulation Langchuang Recipes series on subsets of T lymphocytes Th and Tc in patients with systemic lupus erythematosus *
TAO Xiao-Juan, Zheng Hong-xia, YU Jian-ning MA Ji-Lin, and Zhang Wen

Objective: To study the principle of compensation Fei, cooling blood and detoxification and nourishing yin and moisening Fei (abbreviated as CCD-NM) in regulating levels of subsets of peripheral lymphocytes and T- Tc Th cells to explore the mechanism for lowering the incidence of infection in patients with systemic lupus erythematosus (SLE). Methods: Sixty patients with SLE without complicated infection were assigned to experimental group and the control group, 30 in each group. The control group was treated with Western medicine alone, while the treatment group was treated with the same program of Western medicine, but in addition, be administered with 1 or 2 Langchuang series of concerted Chinese recipes, applied respectively in patients in active phase or the resting stage. The total duration of treatment for both groups was 1 year. In addition, healthy controls has been established with 20 healthy subjects. Expressions of Thl, Th2, Tcl and Tc2 cells and peripheral blood were detected and compared with those of healthy control group. Results: (1) Compared with healthy controls, the ratios of Thl/Th2 Tcl/Tc2 and in patients with SLE, complicated with infection or not, were significantly lower (P <0.05 or P < 0.01). (2) The comparison between patients with complications and those with uncomplicated infection showed that the two reports Thl and expression were weaker and Tc2 was higher in the former than the latter (all P < 0.05). (3) and Tcl/Tc2 Thl/Th2 ratios increased after treatment among patients in both treatment groups and control group (P <0.05 and p <0.01), but changes in the treatment group were more significant (P <0.05).
Conclusion: The principle of the CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients, which could be one of the mechanisms of action to reduce the complicated infection.
KEY WORDS Langchuang No.l, No.2 Langchuang, lupus erythematosus, infection, Th and Tc subsets of T lymphocytes

Systemic lupus erythematosus (SLE) is a kind of autoimmune disease involving multiple systems of the body. With the wide application of glucocorticoids and immunosuppressive drugs, the prognosis of patients with SLE has been obviously improved, but the infection is still an important factor affecting prognosis. Repeated clinical studies have shown that infection complicated and raised serious complications remain the most common cause for a prolonged period (1,2). From the perspective of the theory of TCM, the authors used the principle of compensation Fei (?), Cooling blood and detoxification and nourishing yin and moistening Fei (abbreviated as CCD-NM) clinical practice, and we found that shows an advantage in the fight against the complications of SLE (3), and could regulate the levels of the Th subsets and Tc cells, suggesting that it is Perhaps one of the mechanisms of action to prevent infection in SLE patients. The study is reported as follows.

METHODS

Diagnostic Standard
The standard LED diagnostic issued by the American Association of Rheumatology (revised edition, 1982) (4) was adopted, the state of the disease was judged by the SLE activity index (AI) and calculated according to literature (5), AI? 5 was considered to be in active phase? 4, resting stage.

The diagnosis of a complicated infection depends on: (1) signs and symptoms confirmable, (2) film tracing the evolution of chest infiltration into the lung tissue, cardiac and pulmonary ed.

Posted on May 13, 2011.
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